Nature

Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease

Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide 1. CAD has a strong genetic component with an estimated heritability of 40–60% (ref. 2). Large-scale genome-wide ...
Nature

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary ...