Through surface receptors, mammalian cells constantly perceive informational flow from the extracellular milieu. The information from the receptors is transmitted through cellular signalling cascades, ...

The well-established existence of sex differences in immune responses, including immune responses driven by T cells, cuts both ways. Females tend to have a stronger immune response to pathogens, yet ...

Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood.

Sterols, such as cholesterol in our bodies or ergosterol in yeast cells, are among the most abundant lipids in eukaryotic cells, yet are synthesized through notoriously long, complex metabolic ...

Researchers at ETH Zurich have identified a compound that blocks the aggregation of GRK2, a kinase protein whose clumping ...

Dendritic cells (DCs) are among the first immune sentinels to detect viruses, bacteria, or other challenges. These specialized messengers alert T cells while orchestrating either a measured calm or a ...

Researchers found that KAT7 promotes CMPK2-driven mitochondrial DNA release in microglia, activating inflammatory cGAS-STING ...

New scientific methods could one day render animal studies—the standard in research laboratories for more than 100 years—obsolete. Clive Svendsen, Ph.D., executive director of the Board of Governors ...

Scientists at the University of Western Australia and the Perron Institute for Neurological and Translational Science have made a breakthrough in understanding how cells in our body respond to ...

Established laboratory tests mainly capture average values across many cells and show, for example, how many cancer cells survive after contact with immune cells.