A distinct signaling pathway called TNF- drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF- program and become invasive ...

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer. While indispensable for embryonic patterning ...

Notoriously tricky to detect, pancreatic cancer also often resists traditional therapy. So, researchers are urgently looking for new ways to disrupt tumor formation. Though scientists know that the ...

Researchers at Åbo Akademi University have identified a new molecular change in patients with colorectal cancer and developed a genetic disease model that forms tumors in the large intestine, ...

Researchers have shown how a low carbohydrate diet can worsen the DNA-damaging effects of some gut microbes to cause colorectal cancer. The study compared the effects of three different diets in ...

The same cellular renewal that keeps our bodies healthy might also fuel the growth of cancer. A UC Merced biologist has found that the brain could hold the key to stopping it. Professor Néstor Oviedo, ...

Goto et al. 1 recently described a novel mechanism of immune evasion during the initial steps in the development of colorectal cancer in which nascent cancer cells reactivate a fetal program that is ...