Docking experiments showed that c-di-GMP would not bind the CLP of other isoforms, such as HCN1 and HCN2 (Supplementary Fig. 1b). Although the CLP binding pocket has a high sequence homology within ...

KCNH channels are part of a large family of cyclic-nucleotide-regulated channels that includes the HCN and cyclic-nucleotide-gated (CNG) channels (Supplementary Fig. 1a). Unlike HCN and CNG channels ...