A new type of cancer cell that "warrants urgent investigation" has been discovered in childhood leukemia and could impact ...

New research suggests that DNA variants help predict toxicity and response in CAR T-cell therapy for large B-cell lymphoma.

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Discovery of a new cancer cell type could enable testing to predict treatment-resistant blood cancer in children with a certain type of leukaemia. This could allow them to reduce treatment intensity ...

Researchers from the School of Veterinary Medicine and Perelman School of Medicine have found that YY1 knockout pro-B cells can generate T lineage cells helping B cells produce antibodies. Development ...

Chimeric antigen receptor (CAR) T-cell therapies have transformed cancer and autoimmune disease treatment. Modified CAR proteins equip T cells with the ability to identify and eliminate cancer cells ...

In a groundbreaking development for cancer treatment, Caribou Biosciences announced promising results from its off-the-shelf CAR-T therapy in patients with advanced B-cell lymphoma. This innovative ...

Viruses are effective tools for delivering genetic material into cells, and scientists have taken advantage of viral transduction in numerous ways, such as constructing chimeric antigen receptor (CAR) ...