Researchers identified a key receptor that primes the formation of autoreactive B cells. Disrupting this pathway may be a ...

B cells and the antibodies they produce play an important role in our immune system, protecting us from the microscopic enemies that make us ill. Uncovering how they form and are 'programmed' during ...

A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint ...

Ataxin-1 (ATXN1) is a ubiquitous polyglutamine protein expressed primarily in the nucleus where it binds chromatin and functions as a transcriptional repressor. Mutant forms of ataxin-1 containing ...

Cells have an internal skeleton that maintains their structure and also drives their movement. Known as the cytoskeleton, ...

These findings from research into diffuse large B cell lymphoma (DLBCL) are based on analyses of human patients and a murine model. The immunosuppressive role of fibroblastic reticular cells (FRCs) in ...

A new study reveals how Epstein–Barr virus reprogrammes B cells into autoimmune drivers, uncovering a direct mechanism linking EBV infection to lupus development.

There are currently ~38 million people worldwide living with HIV. If left untreated, HIV infection progresses to acquired immunodeficiency syndrome (AIDS) where patients become extremely vulnerable to ...

Learn about B-Cell Acute Lymphoblastic Leukemia (B-ALL), its symptoms, diagnosis, causes, and treatment options. Understand how B lymphocytes affect leukemia ...