Skyy Moore didn't make it to the main Pro Bowl roster, but he was selected as an alternate. The strong stretch of performances in the last five games has got him there. Moore is yet another solid addition the 49ers made, and one that will aid them come playoff time.

The San Francisco 49ers dominated the Indianapolis Colts on Monday night, with veteran left tackle Trent Williams leading a strong offensive line and the team strengthening its NFC playoff positioning.

Trent Williams’ Hall of Fame career won’t be ending anytime soon. The 49ers offensive lineman said following San Francisco’s 48-27 victory over the Colts on Monday night that he’s “nowhere near done.” “We got a few more years,

The San Francisco 49ers beat the Indianapolis Colts on Monday. How did their performance affect their standing heading into Week 17?

San Francisco secured a postseason berth following the Lions’ loss and now looks ahead to positioning for the top NFC seed, with Kyle Shanahan emphasizing a measured, championship-focused approach.

The Baltimore Ravens, Denver Broncos, San Francisco 49ers and Seattle Seahawks tied for an NFL-best six selections apiece for the 2026 Pro Bowl Games.

The San Francisco 49ers' last road trip of the regular season was a successful one. The Niners clinched a playoff spot while in their hotel on Sunday, beat the Indianapolis Colts 48-27 on Monday night and returned home knowing they now have a chance to go on a Super Bowl run without hitting the road again until next

After 49ers starting QB Brock Purdy suffered turf toe in his right foot in a 17-13 Week 1 win over the Seattle Seahawks, backup QB Mac Jones replaced him. Purdy would return in a 26-21 Week 4 loss to the Jacksonville Jaguars but reaggravated the injury, missing six more games.

The San Francisco 49ers were healthy in the first quarter against the the Indianapolis Colts, but the injuries are piling up in the third quarter.