A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago Bears in Week 17 and then take on the Seattle Seahawks in Week 18. The Seattle-San Francisco regular-season finale could be the No. 1 overall seed in the NFC and the NFC West title.

Brock Purdy stats: 49ers QB makes MNF history with career game vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.

“Injury Update: George Kittle is questionable to return (ankle),” the team posted on X.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

While the 49ers have won a fifth consecutive game, the Colts have now lost five straight. Here's the winners and losers from "Monday Night Football."