The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 49ers are serious title contenders.

It's one thing to respect your elders, but the 49ers' young defensive players were taking it a little too far early on Monday night.

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never get completely healthy, it is significant to note that they will potentially be getting three significant contributors back on the defensive side of the football in Week 16 against the Indianapolis Colts.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

San Francisco 49ers left tackle Trent Williams says he's "nowhere near done" playing football and has multiple years left before he retires.

It's been surprising to see how successful the San Francisco 49ers have been this year. To be 11-4 with a chance at earning the No. 1 playoff seed in the NFC wi

The 49ers may have offensive tackle Trent Williams around for longer than expected after his comments following their win over the Colts.

The San Francisco 49ers have been in punt avoidance mode, making NFL history and leaving Thomas Morstead bored out of his mind.