So, while the Colts' defense wasn't able to spread any Christmas cheer to their fans in Indy, at least the offense was in a giving mood. This article originally published at 49ers' thrashing of Colts stifled NFL's biggest celebration artist.

Brock Purdy and the San Francisco 49ers earned a statement 48–27 road win over Philip Rivers and the Indianapolis Colts on Monday Night Football, as both quarterbacks put on an entertaining aerial showcase.

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Sunday Night Football game between Chicago Bears and San Francisco 49ers.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

San Francisco 49ers quarterback Brock Purdy did a favor for three AFC teams by throwing five touchdown passes in a 48-27 victory over the Indianapolis Colts on Monday night.

Highlights from the Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts during the 2025 NFL season.

Jonathan Taylor and the Indianapolis Colts came up short on Monday night, suffering defeat against a red-hot San Francisco 49ers side. The Colts put up a respectable fight, but they just couldn’t compete with the Niners, who have now stacked up five straight victories.

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the Indianapolis Colts.