The main event will see Dricus du Plessis attempt to defend his middleweight belt for the second time when he and Sean Strickland square off in a rematch of their 2024 meeting. Strickland rebounded from losing his title with a split decision over former title challenger Paulo Costa at UFC 302,

UFC middleweight champion Dricus du Plessis has Sean Strickland to fend off at UFC 312, but there's a wolf on the hunt. Khamzat Chimaev is next in line for a title shot and many are convinced he'll win.

Everything you need to know about the main event of the UFC 312 fight card: Dricus du Plessis vs. Sean Strickland 2. Betting odds, picks, predictions and more.