The San Francisco 49ers on Saturday placed Brandon Aiyuk on the reserve/left squad list, ending his 2025 season and likely severing the team’s ties with the talented wide receiver for the future.

Brandon Aiyuk’s time with the 49ers might be over. The wide receiver, who hasn’t played since he underwent right knee surgery in the middle of last season, was placed on the team’s reserve/left team list on Saturday. The move leaves Aiyuk ineligible to return to San Francisco this season.

It's clear the 49ers are relying on Pearsall to become Aiyuk's successor in the receiving corps — this season and in the future.